Quinolines and derivatives
Medchemexpress LLC Mal-amido-PEG12-acid | 2378428-27-2 | C34H60N2O17 | 50 MG
Mal-amido-PEG12-acid is a PEG-based PROTAC linker suitable for synthesizing PROTACs. It functions by connecting two distinct ligands, one targeting an E3 ubiquitin ligase and the other for the specific target protein, allowing for the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Can be used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC Azide-PEG-amine | 95.0% | 100 MG
Azide-PEG-amine (MW 5000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This molecule functions as a versatile click chemistry reagent, enabling crucial reactions in chemical biology and drug discovery.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC MPEG-amine (MW 20000) | 80506-64-5 | 98.0% | (C2H4O)nC3H9NO | 100 MG
m-PEG-NH2 (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Purity: 98.0%
Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 1 MG
ACT-1004-1239 is a potent, selective, orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It is intended for research use only.
- Inhibits human, dog, rat, mouse, guinea pig, macaque CXCR7 with IC50s of 3.2, 2.3, 3.1, 2.3, 0.6, 1.5 nM respectively.
- Promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels.
- Increases plasma CXCL12 concentration in naive male DBA/1 mice.
- Reduces disease severity in MOG-induced experimental autoimmune encephalomyelitis (EAE) model.
- Increases myelination in the Cuprizone-induced demyelination model mice.
Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 50 MG
ACT-1004-1239 is a potent, selective, and orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels. In animal models, it has been shown to reduce disease severity in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) and increase myelination in Cuprizone-induced demyelination models. This product is for research use only.
- Potent, selective, and orally active CXCR7 antagonist
- IC50 value of 3.2 nM
- Promotes oligodendrocyte precursor cell (OPC) differentiation
- Increases CXCL12 levels
- Reduces disease severity in MOG-induced experimental autoimmune encephalomyelitis (EAE) in animal models
- Increases myelination in Cuprizone-induced demyelination models
- For research use only
Aobchem 5-Trimethyl-2-pyridineacetonitrile | ≥95% | CAS 929021-97-6 | C10H12N2 | 250mg
5-Trimethyl-2-pyridineacetonitrile | ≥95% | CAS 929021-97-6 | C10H12N2 | 250mg
Medchemexpress LLC 6-Aminoquinoline | 580-15-4 | MFCD00006803 | 144.17 | 25 G
6-Aminoquinoline is a biochemical reagent used as a biological material or organic compound for life science related research. It is intended for research use only.
- Biochemical reagent for life science research
- Solid appearance, light yellow to brown color
- Purity of 99.79%
- Molecular weight of 144.17
- Store at 4°C, protect from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month (protect from light)
Aobchem 3-Bromo-1H-quinolin-2-one | ≥95% | CAS 939-16-2 | C9H6BrNO | 10g
3-Bromo-1H-quinolin-2-one | ≥95% | CAS 939-16-2 | C9H6BrNO | 10g
Aobchem 2-Fluoro-3-isopropoxy-5-methylbenzaldehyde | 97% | CAS 2755718-46-6 | C11H13FO2 | 1g
2-Fluoro-3-isopropoxy-5-methylbenzaldehyde | 97% | CAS 2755718-46-6 | C11H13FO2 | 1g